Research

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New technologies capable of measuring multiple characteristics of single cells and populations of cells (100 to 1,000,000) accelerate the understanding of the macroscopic responses of multicellular biological systems and their collective properties. We focus on developing methods to determine multiple qualities that define the identity, function, and genetic content of individual cells, with an emphasis on measuring the state of single cells with great breadth and depth.  Using these tools, we aim to construct detailed profiles that describe the state and evolution of a multicellular population.  Such profiles enable a greater understanding of disease signatures that characterize immune responses, of how biological variations contribute to phenotypes, and of rare populations of cells important in disease and interventions.  Such knowledge could ultimately transform how we understand human health.

The applications for the technologies for single-cell analysis that we are pursuing include clonal selection for bioprocess manufacturing, discovery of new immunotherapies, and performing immunological monitoring for diagnosis and biomedical research in clinical immunology. 

In addition to these technologies, we seek to develop new approaches to manufacturing of biopharmaceuticals that could improve how and where they are produced for patients, and ultimately their accessibility globally. 

Allergy

Allergy

Food allergies are a major problem in the industrialized world, affecting 5% of children in the United States. more >>

Autoimmunity

Autoimmunity

T cells play a central role in mediating the physiological response to infection and injury through various effector functions, such as cytokine secretion. more >>

bcellphylogeny

B cells

Antibodies are proteins generated by B cells as part of a humoral immune response, and play an important role in conferring immunological protection to infectious diseases through both natural exposure and vaccination. more >>

biomanufacturing

Biomanufacturing

Biologic drugs, including those used for the treatment of cancer, are currently manufactured using processes that are not only time-consuming but also extremely expensive. more >>

Cancer

Cancer

Many cancers are an inflammatory disease of tissue, comprising millions to billions of malignant and stromal cells. more >>

   
Technology development

Technology development

Each cell in the human body carries a wealth of information: the genes it expresses, the molecules it produces, the functions it performs, and, perhaps, the pathogens that it is infected with.... more >>