Bioprocess development refers to the activities undertaken to understand the relationships between process parameters and process outputs for the purposes of developing a viable, ideally optimized, biomanufacturing process. Given the associated complexity, developing a bioprocess is time-consuming and costly, with traditional methods relying on extensive experimentation and trial-and-error approaches. We are actively researching advanced approaches to bioprocess development for streamlined developmental lifecycles, reduced costs, and maximized production efficiencies. Additionally, we are interested in improving efficiencies and outputs through intensified fed-batch and perfusion strategies. Through this work, we aim to achieve industrially-relevant protein production quantities at a fraction of the time and cost of current industrial production platforms.
(from “Accelerating cell culture media development using Bayesian optimization-based iterative experimental design, Narayanan et al. 2025″)
Relevant Papers
Narayanan H, Hinckley JA, Barry R, Dang B, Wolffe LA, Atari A, Tseng YY, Love JC. Accelerating cell culture media development using Bayesian optimization-based iterative experimental design. Nat Commun. 2025 Jul 1;16(1):6055. doi: 10.1038/s41467-025-61113-5. PMID: 40593792; PMCID: PMC12218302.
Biedermann AM, Gengaro IR, Rodriguez-Aponte SA, Love KR, Love JC. Modular development enables rapid design of media for alternative hosts. Biotechnol Bioeng. 2022 Jan;119(1):59-71. doi: 10.1002/bit.27947. Epub 2021 Oct 18. PMID: 34596238; PMCID: PMC9298315.